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plasma metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (9) Endogenous Metabolite (10) Androgen Receptor (2) Angiotensin Receptor (2) BCRP (3) Calcium Channel (1) Cholinesterase (ChE) (1) Cytochrome P450 (1) EGFR (2) FLT3 (2) Isotope-Labeled Compounds (7) Parasite (4) Proton Pump (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (4) Endocrinology (1) Infection (5) Metabolic Disease (7) Neurological Disease (5)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Metabolite Endogenous Metabolite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12388A

N-Desmethyl Clomipramine hydrochloride Desmethylclomipramine hydrochloride	Drug Metabolite	Neurological Disease
N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .

HY-12388AS

N-Desmethyl Clomipramine D3 hydrochloride Desmethylclomipramine D3 hydrochloride	Drug Metabolite	Neurological Disease
N-Desmethyl Clomipramine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]

HY-113161

L-Octanoylcarnitine	Endogenous Metabolite	Cancer
L-Octanoylcarnitine is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine can be used for the research of breast cancer .

HY-W354498

L-Octanoylcarnitine hydrochloride	Endogenous Metabolite	Cancer
L-Octanoylcarnitine hydrochloride is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine hydrochloride can be used for the research of breast cancer .

HY-113161S

L-Octanoylcarnitine-d3	Isotope-Labeled Compounds	Others
L-Octanoylcarnitine-d₃ is the deuterium-labeled L-Octanoylcarnitine (HY-113161). L-Octanoylcarnitine-d₃ is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine-d₃ can be used for the research of breast cancer .

HY-I0177

Vilazodone carboxylic acid

Drug Metabolite Others

Vilazodone carboxylic acid is a vilazodone metabolite observed in both urine (major) and plasma (minor) .
HY-N8210

Homoeriodictyol

Drug Metabolite Others

Homoeriodictyol is a flavonoid metabolite of Eriocitrin in plasma and urine. Eriocitrin is a strong antioxidant agent .

Vilazodone carboxylic acid	Drug Metabolite	Others
Vilazodone carboxylic acid is a vilazodone metabolite observed in both urine (major) and plasma (minor) .

Homoeriodictyol	Drug Metabolite	Others
Homoeriodictyol is a flavonoid metabolite of Eriocitrin in plasma and urine. Eriocitrin is a strong antioxidant agent .

HY-Y0202

Pyrocatechuic acid Catecholcarboxylic acid; NSC 27435	Endogenous Metabolite	Others
Pyrocatechuic acid is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion.

HY-135174

L-Cysteine-glutathione disulfide	Others Endogenous Metabolite	Infection
L-Cysteine-glutathione disulfide is a metabolite in plasma that can be used in biomarker studies for tuberculosis cure .

HY-113168

Butyrylcarnitine	Endogenous Metabolite	Others
Butyrylcarnitine is a metabolite in plasma, acts as a biomarker to improve the diagnosis and prognosis of heart failure, and is indicative of anomalous lipid and energy metabolism.

HY-N0873A

Iso-Sagittatoside A	Drug Metabolite	Others
Iso-Sagittatoside A is the metabolite of effective Erxian Decoction (EXD, a Chinese medicine prescription for menopausal syndromes) in rat plasma .

HY-122317

Menthol glucuronide

Drug Metabolite Others

Menthol glucuronide, a metabolite of Menthol (HY-N1369), is a plasma and urine biomarker of acute Menthol inhalation .

Menthol glucuronide	Drug Metabolite	Others
Menthol glucuronide, a metabolite of Menthol (HY-N1369), is a plasma and urine biomarker of acute Menthol inhalation .

HY-W004206

2-(4-Methoxyphenyl)acetic acid 4-Methoxyphenylacetic acid	Endogenous Metabolite	Cancer
2-(4-Methoxyphenyl)acetic acid is a plasma metabolite, with high sensitivity and specificity value as a biomarker for discriminating between NSCLC and healthy controls.

HY-W011239

Fenbendazole sulfone Oxfendazole sulfone; FBZ-SO2	Parasite	Infection
Fenbendazole sulfone (Oxfendazole sulfone;FBZ-SO2) is a minor metabolite of Fenbendazole in plasma and is a benzimidazole anthelmintic agent .

HY-N11429

Glycochenodeoxycholic acid 3-glucuronide	Others	Metabolic Disease Cancer
Glycochenodeoxycholic acid 3-glucuronide is a type of steroid glucuronide and a plasma metabolite that can be used for biomarker research in diabetes and hepatocellular carcinoma (HCC) .

HY-N4173

8-Oxoepiberberine	Drug Metabolite	Metabolic Disease
8-Oxoepiberberine is an alkaloid metabolite in the plasma after oral administration of Zuojin formula, a traditional chinese medicine used to treat gastrointestinal disease .

HY-70002A

N-desmethyl Enzalutamide N-desmethyl MDV 3100	Androgen Receptor	Cancer
N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .

HY-135245

Ezetimibe hydroxy glucuronide SCH 488128; Ezetimibe hydroxy β-D-Glucuronide	Drug Metabolite	Cardiovascular Disease
Ezetimibe hydroxy glucuronide (SCH 488128) is a trace metabolite detected in dog and human plasma samples after oral administration of Ezetimibe (HY-17376) .

HY-114297

Zymosterol	Endogenous Metabolite	Others
Zymosterol is a Cholesterol (HY-N0322) biosynthesis metabolite. Zymosterol, a precursor of Cholesterol, is found mostly in the plasma membrane. Zymosterol circulates within the cell .

HY-W042039

Methyl homoveratrate	Calcium Channel	Cardiovascular Disease
Methyl homoveratrate, a metabolite of RWJ-26240 in vivo, can be identified in plasma, urine and faecal extract. McN5691 (RWJ-26240) is a voltage-sensitive calcium channel blocker .

HY-N6910

Pseudolaric Acid C2	Others	Metabolic Disease
Pseudolaric Acid C2, a diterpenoid isolated from Pseudolarix kaempferi, is identified as the specific metabolite of Pseudolaric acid B in plasma, urine, bile and feces after both oral and intravenous administration to rats .

HY-136450

Triclabendazole sulfoxide TCBZ-SO	Parasite BCRP	Infection
Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP .

HY-113113

13,14-Dihydro PGE1 13,14-Dihydroprostaglandin E1	Endogenous Metabolite	Metabolic Disease
13,14-Dihydro PGE₁ is a metabolite of PGE₁ (Prostaglandin E1) which inhibits the ADP-induced platelet aggregation (ID₅₀ = 10.8 ng/mL platelet rich plasma) .

HY-70002AS

N-desmethyl Enzalutamide-d6 N-desmethyl MDV 3100-d6
N-desmethyl Enzalutamide-d₆ is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1].

HY-100064

O-Desmethyl gefitinib
O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC₅₀ of 36 nM in subcellular assays .

HY-12388AR

N-Desmethyl Clomipramine hydrochloride (Standard) Desmethylclomipramine hydrochloride (Standard)	Drug Metabolite	Neurological Disease
N-Desmethyl Clomipramine (hydrochloride) (Standard) is the analytical standard of N-Desmethyl Clomipramine (hydrochloride). This product is intended for research and analytical applications. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .

HY-W017100

2-Hydroxy-6-methoxybenzoic acid 6-Methoxysalicylic acid	Others	Neurological Disease
2-Hydroxy-6-methoxybenzoic acid can be used for the determination of acetylsalicylic acid and its major metabolite, salicylic acid, in animal plasma. 2-Hydroxy-6-methoxybenzoic acid exhibits significant analgesic effects .

HY-B0815S

Chlorpyrifos-d10	Cholinesterase (ChE)	Neurological Disease
Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

HY-118283

5-Hydroxylansoprazole 1 Publications Verification AG1908	Proton Pump	Metabolic Disease
5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma. Lansoprazole is metabolized by CYP2C19 forming 5-Hydroxylansoprazole. Lansoprazole is a gastric proton-pump inhibitor and is effective in the treatment of various peptic diseases .

HY-136450S

Triclabendazole sulfoxide-d3 TCBZ-SO-d₃	Isotope-Labeled Compounds Parasite BCRP	Infection
Triclabendazole sulfoxide-d₃ is the deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].

HY-112948

2-Methylbutyrylcarnitine	Endogenous Metabolite	Metabolic Disease
2-Methylbutyrylcarnitine is a fatty acid metabolite. 2-Methylbutyrylcarnitine is found mainly in the blood and urine of humans and animals and is produced through the pyruvate carboxylation pathway. 2-Methylbutyrylcarnitine exhibits high level in the plasma of subjects with steatohepatitis (NASH) and can be used as an indicator for the diagnosis of metabolic diseases .

HY-100064S

O-Desmethyl gefitinib-d8	EGFR	Cancer
O-Desmethyl gefitinib-d₈ is a deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].

HY-100064S1

O-Desmethyl gefitinib-d6	Isotope-Labeled Compounds EGFR	Cancer
O-Desmethyl gefitinib-d₆ is the deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].

HY-136450S1

Triclabendazole sulfoxide-13C,d3 TCBZ-SO-¹³C,d₃	Isotope-Labeled Compounds Parasite BCRP	Infection
Triclabendazole sulfoxide- ¹³C,d₃ is the ¹³C- and deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].

HY-137591

13,14-Dihydro-15-keto-PGE1	Others	Endocrinology
13,14-Dihydro-15-keto-PGE1 is an inactive metabolite of PGE1. 13, 14-Dihydro-15-Keto-pGE1 inhibited platelet aggregation in ADP-induced human isolated platelet-rich plasma with IC₅₀ 14.8 μg/mL .

HY-108263

3-Hydroxy Midostaurin CGP52421	FLT3	Cancer
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC₅₀s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 .

HY-108263S

3-Hydroxy Midostaurin-d5 CGP52421-d₅	Isotope-Labeled Compounds FLT3	Cancer
3-Hydroxy Midostaurin-d₅ is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].

HY-N6720

T-2 Triol	Endogenous Metabolite	Metabolic Disease
T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin . T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t_1/2λz), Peak plasma concentrations (C_max) and T_max values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively .

HY-135331

N-Desmethyl-Apalutamide	Androgen Receptor Cytochrome P450	Cancer
N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-12765

Losartan Carboxylic Acid E-3174; EXP-3174	Angiotensin Receptor	Cardiovascular Disease
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K_i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .

HY-W754151

N-Desmethyl apalutamide-d4	Isotope-Labeled Compounds	Others
N-Desmethyl apalutamide-d₄ is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-12765S1

Losartan carboxylic acid-d4 hydrochloride	Isotope-Labeled Compounds Angiotensin Receptor	Cardiovascular Disease
Losartan carboxylic acid-d₄ (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113161

L-Octanoylcarnitine	Structural Classification Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Octanoylcarnitine is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine can be used for the research of breast cancer .

HY-W354498

L-Octanoylcarnitine hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
L-Octanoylcarnitine hydrochloride is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine hydrochloride can be used for the research of breast cancer .

HY-N8210

Homoeriodictyol	Structural Classification Flavonoids other families Classification of Application Fields Flavonones Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Drug Metabolite
Homoeriodictyol is a flavonoid metabolite of Eriocitrin in plasma and urine. Eriocitrin is a strong antioxidant agent .

HY-Y0202

Pyrocatechuic acid Catecholcarboxylic acid; NSC 27435	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Pyrocatechuic acid is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion.

HY-113168

Butyrylcarnitine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Butyrylcarnitine is a metabolite in plasma, acts as a biomarker to improve the diagnosis and prognosis of heart failure, and is indicative of anomalous lipid and energy metabolism.

HY-N0873A

Iso-Sagittatoside A	Flavonols Flavonoids Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Drug Metabolite
Iso-Sagittatoside A is the metabolite of effective Erxian Decoction (EXD, a Chinese medicine prescription for menopausal syndromes) in rat plasma .

HY-W004206

2-(4-Methoxyphenyl)acetic acid 4-Methoxyphenylacetic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
2-(4-Methoxyphenyl)acetic acid is a plasma metabolite, with high sensitivity and specificity value as a biomarker for discriminating between NSCLC and healthy controls.

HY-N11429

Glycochenodeoxycholic acid 3-glucuronide	Triterpenes Structural Classification Terpenoids Source classification Endogenous metabolite	Others
Glycochenodeoxycholic acid 3-glucuronide is a type of steroid glucuronide and a plasma metabolite that can be used for biomarker research in diabetes and hepatocellular carcinoma (HCC) .

HY-N4173

8-Oxoepiberberine	Structural Classification other families Stilbenes Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Drug Metabolite
8-Oxoepiberberine is an alkaloid metabolite in the plasma after oral administration of Zuojin formula, a traditional chinese medicine used to treat gastrointestinal disease .

HY-114297

Zymosterol	Structural Classification Microorganisms Source classification Endogenous metabolite Steroids	Endogenous Metabolite
Zymosterol is a Cholesterol (HY-N0322) biosynthesis metabolite. Zymosterol, a precursor of Cholesterol, is found mostly in the plasma membrane. Zymosterol circulates within the cell .

HY-N6910

Pseudolaric Acid C2	other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Diterpenoids Plants Disease Research Fields	Others
Pseudolaric Acid C2, a diterpenoid isolated from Pseudolarix kaempferi, is identified as the specific metabolite of Pseudolaric acid B in plasma, urine, bile and feces after both oral and intravenous administration to rats .

HY-W017100

2-Hydroxy-6-methoxybenzoic acid 6-Methoxysalicylic acid	Monophenols Securidaca inappendiculata Hassk. Ketones, Aldehydes, Acids Source classification Polygalaceae Phenols Plants	Others
2-Hydroxy-6-methoxybenzoic acid can be used for the determination of acetylsalicylic acid and its major metabolite, salicylic acid, in animal plasma. 2-Hydroxy-6-methoxybenzoic acid exhibits significant analgesic effects .

HY-112948

2-Methylbutyrylcarnitine	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Methylbutyrylcarnitine is a fatty acid metabolite. 2-Methylbutyrylcarnitine is found mainly in the blood and urine of humans and animals and is produced through the pyruvate carboxylation pathway. 2-Methylbutyrylcarnitine exhibits high level in the plasma of subjects with steatohepatitis (NASH) and can be used as an indicator for the diagnosis of metabolic diseases .

HY-N6720

T-2 Triol	Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin . T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t_1/2λz), Peak plasma concentrations (C_max) and T_max values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively .

Cat. No.	Product Name	Chemical Structure

HY-12388AS

N-Desmethyl Clomipramine D3 hydrochloride
N-Desmethyl Clomipramine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]

HY-B0815S

Chlorpyrifos-d10

Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

HY-100064S

O-Desmethyl gefitinib-d8
O-Desmethyl gefitinib-d₈ is a deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].

HY-113161S

L-Octanoylcarnitine-d3
L-Octanoylcarnitine-d₃ is the deuterium-labeled L-Octanoylcarnitine (HY-113161). L-Octanoylcarnitine-d₃ is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine-d₃ can be used for the research of breast cancer .

HY-136450S

Triclabendazole sulfoxide-d3
Triclabendazole sulfoxide-d₃ is the deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].

HY-100064S1

O-Desmethyl gefitinib-d6
O-Desmethyl gefitinib-d₆ is the deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].

HY-136450S1

Triclabendazole sulfoxide-13C,d3
Triclabendazole sulfoxide- ¹³C,d₃ is the ¹³C- and deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].

HY-108263S

3-Hydroxy Midostaurin-d5
3-Hydroxy Midostaurin-d₅ is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].

HY-W754151

N-Desmethyl apalutamide-d4

N-Desmethyl apalutamide-d₄ is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-12765S1

Losartan carboxylic acid-d4 hydrochloride

Losartan carboxylic acid-d₄ (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].

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plasma metabolite

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